I have a mature Green Tree Python. I thought it was going to take a while to get her to eat one of these. She has now had two feedings. Feeding #1 took a strike and was unsure of what this was and released, second strike was a great feeding response, constricted but took a couple minutes to orient herself to swallow, ultimately went well. Feeding #2. Handled it like a pro. No issues, might as well been a F/T rat or quail. I'm sold. Not sure if I'll use them 100% of the time but my wife sure is happier having these in the freezer next to the ice cream instead of the frozen rats. :)